The Wechsler Intelligence Scale for Children-III (WISC-III) is a well-known measure of overall childhood intelligence, as reflected in Verbal and Performance IQ, as well as in Total IQ 7. Intelligence quotient, IQ, is a measure of cognition known to associate with academic achievement 4, 5 children‘s IQ scores are predictive of their educational attainment as adults 4, 5, 6. However, it has not been established whether they do so through general cognitive ability (cognitive g), or through more specific forms of cognition, and the medium through which they affect educational attainment remains unexplained for the majority of them. To date it has been established that some educational attainment markers are also associated with cognition 1, 2, 3.
Large genome-wide association studies have been performed (n > 400,000) on educational attainment, yielding sets of significant sequence markers. P = 1.0 × 10 −5).Įducational attainment can be conceived of as a representation of the cognitive processes necessary for progressive acquisition of knowledge and skills, collectively defined as intelligence, along with the drive of an individual in the right environment. Childhood cognition is unlikely to be affected by education attained later in life, and the variant explains a greater fraction of the variance in verbal IQ than in educational attainment (0.7% vs 0.12%. corresponds to 1.4 IQ points for heterozygotes and 2.8 IQ points for homozygotes. We show that one of these variants associating with educational attainment, rs4851266-T, also associates with Verbal IQ in dyslexic children ( P = 4.3 × 10 −4, β = 0.16 s.d.). Recently, three sequence variants were shown to associate with educational attainment, a confluence phenotype of genetic and environmental factors contributing to academic success.
Here we demonstrate that polygenic scores of educational attainment predict specific aspects of childhood cognition, as measured with IQ. Only a few common variants in the sequence of the genome have been shown to impact cognitive traits.
0 kommentar(er)
